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基于mRNA-脂质纳米颗粒技术的抗立克次体感染纳米抗体开发研究
研究高潮在于mRNA-LNP递送系统的成功应用。体外实验显示,A44和A123 mRNA-LNP处理使HEK293细胞的感染率显著降低;小鼠模型中,静脉注射纳米抗体mRNA-LNP后,血液、肝脏和脾脏的细菌载量均明显下降,且未观察到不良反应。
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