Background— Ventilatory efficiency, commonly assessed by the minute ventilation (V̇e)–carbon dioxide production (V̇co2) slope, is a powerful prognostic marker in the heart failure population. The ...

Coronary atherosclerosis is by far the most frequent cause of ischemic heart disease, and plaque disruption with superimposed thrombosis is the main cause of the ...

The aim of this study was to identify the relative impact of adrenergic and cholinergic activity on atrial fibrillation (AF) inducibility and blood pressure (BP) in a model for obstructive sleep apnea ...

Suppression of prostacyclin (PGI2) biosynthesis may explain the increased incidence of myocardial infarction and stroke which has been observed in placebo controlled trials of cyclooxygenase (COX)-2 ...

Reducing blood pressure (BP) is a highly effective strategy for long-term stroke prevention. Despite overwhelmingly clear evidence from randomized trials that antihypertensive therapy substantially ...

Objective— We investigated the impact of several genetic variants located in genes encoding for proteins involved in biogenesis, maturation, and intravascular remodeling of high density lipoprotein ...

Background—Activation of innate pattern-recognition receptors promotes CD4+ T-cell–mediated autoimmune myocarditis and subsequent inflammatory cardiomyopathy. Mechanisms that counterregulate ...

Objective— The Wnt/β-catenin signaling is an ancient and evolutionarily conserved pathway that regulates essential aspects of cell differentiation, proliferation, migration and polarity. Canonical Wnt ...

Background—Progressive familial heart block type I (PFHBI) is a hereditary arrhythmia characterized by progressive conduction disturbances in the His-Purkinje system. PFHBI has been linked to genes ...

Arterial stiffness and BP/hypertension are dynamically interconnected, with each factor influencing the other in a bidirectional manner. Although arterial stiffness was long considered to be a ...

Background—Tissue factor pathway inhibitor (TFPI) is the sole known inhibitor of the extrinsic coagulation pathway of physiological importance; however, its role in modulating thrombosis in vivo is ...

Background— The long-term outcomes of transcatheter aortic valve replacement (TAVR) in inoperable patients with severe aortic stenosis remain unknown.