You can subtract multiple cells from one cell in Excel by using Minus sign, SUM function and Paste Special feature. Here is a tutorial on this.

Learn how to use basic Formulas for mathematical operations & insert Functions like sum, average, count, max, min, date, time, etc. in Excel.

Subtracting isn’t as straightforward in Excel as it seems, simply because there’s no actual command to subtract numbers. Instead, you have to use a formula with the subtraction operator.

In Excel spreadsheets, complex formulas are difficult to enter without making mistakes. Microsoft Excel’s LAMBDA() function can make such errors easier to find.