A female-led Pirates of the Caribbean 6 starring Margot Robbie has been discussed. Though Robbie later said the film was no longer in development, Bruckheimer has still sometimes mentioned it as a possibility. There were also rumors of Disney hoping to cast Karen Gillan in a sixth film.

Bruckheimer previously told EW that he was eager for Depp to return to the role, despite Disney cutting ties with Depp, which the actor claimed happened as a result of the publication of a 2018 op-ed in which his ex-wife, Amber Heard, wrote that she had been a victim of domestic abuse but did not mention Depp by name.

In a recent interview with Entertainment Weekly, Bruckheimer revealed that he has spoken to Depp about coming back for the sixth Pirates film, and the actor is at least open to the idea. The famous Producer explained: If he likes the way the part's written,